5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed in adipose tissue and linked to obesity, insulin resistance, and stem cell aging.
Mechanism: By inhibiting NNMT, intracellular NAD+ and SAM (S-adenosyl methionine) are preserved. Downstream effects include fat mobilization, mitochondrial efficiency, and rejuvenation of muscle stem cells.
Use case: Oral fat-loss adjunct, often stacked with a GLP-1 or GH-axis protocol. Animal studies show selective fat loss without affecting lean mass; human data is preliminary but promising.
Caveats: Strictly speaking, not a peptide. Small molecule. Lives in this category by metabolic-axis mechanism. Research-stage compound; sourcing quality varies widely.