Glossary.
A working reference for the compounds, hormones, prescriptions, supplements, and training concepts that show up in the SYSTEMM protocol. Mechanism-first, plain-language, no fluff. Pick an axis, or jump to the A–Z index →
Native signaling molecules.
Short chains of amino acids. The body's own messengers. GLP-1s, GH secretagogues, healing peptides, neuropeptides, and the cosmetic frontier.
Explore peptides →Dihexa
Angiotensin IV-derived hexapeptide. Potent HGF mimetic — orders of magnitude more synaptogenic than BDNF in animal studies.
Cerebrolysin
Porcine brain-derived peptide complex. Neurotrophic factor mimetic with the strongest stroke-recovery data of any peptide.
ARA-290 (Cibinetide)
Erythropoietin-derived 11-mer. Targets the innate repair receptor for neuropathy and tissue protection without raising hematocrit.
The body's long-range system.
Steroid hormones, thyroid axis, adrenal-stress markers, and the metabolic-pituitary loop. Plus the lab values worth tracking.
Explore hormones →Adiponectin
The 'good' adipokine. Higher levels associated with insulin sensitivity, anti-inflammatory state, and longevity.
ApoB
Apolipoprotein B. The single most informative cardiovascular lipid marker. Counts atherogenic particles directly.
DHT (Dihydrotestosterone)
The potent androgen converted from testosterone by 5-alpha-reductase. Drives hair loss, prostate growth, and sexual function.
The over-the-counter stack.
Vitamins, minerals, adaptogens, nootropics, and the longevity stack. Mechanism, dosing, and the caveats that actually matter.
Explore supplements →5-HTP
Direct serotonin precursor. Crosses the blood-brain barrier; bypasses the rate-limiting step.
Acetyl-L-Carnitine (ALCAR)
Acetylated carnitine. Crosses the blood-brain barrier for mitochondrial and cognitive support.
Boswellia (Boswellic Acids)
Frankincense extract. 5-lipoxygenase inhibitor for inflammatory joint and gut pain.
Off-label prescriptions.
Prescription medications used outside their primary indication. For performance, longevity, aesthetics, sleep, and cognitive support.
Explore Lifestyle Rx →Atorvastatin
Lipophilic statin (Lipitor). The most-prescribed cardiovascular drug. Lowers LDL-C and ApoB.
Anastrozole
Selective aromatase inhibitor. Used on TRT to manage estrogen conversion.
Clomiphene (Clomid)
SERM that boosts endogenous testosterone via the HPG axis. Alternative to direct TRT in younger men.
Metabolism & longevity.
The physiology underneath every protocol. Mitochondria, autophagy, the metabolic state, and the systems that age.
Explore longevity →Glycation
The non-enzymatic reaction of sugars with proteins. The upstream process that creates AGEs.
AGEs (Advanced Glycation End Products)
Sugar-protein cross-link byproducts. Accumulate with age, drive stiffness in tissue, and accelerate cardiovascular decline.
Brown Adipose Tissue (BAT)
Thermogenic fat. Burns calories to produce heat. Activated by cold exposure.
The vocabulary of training.
Strength, conditioning, mobility, and the energy-system principles behind smart programming. Plain-language definitions for serious trainees.
Explore fitness →Anaerobic Threshold
The intensity at which anaerobic energy production dominates. The upper edge of sustainable steady-state.
AMRAP
As many reps (or rounds) as possible. A conditioning and capacity protocol.
Block Periodization
Concentrated training blocks focused on a single quality at a time. Modern alternative to traditional linear periodization.