Activates AMPK, the cellular energy sensor. Lowers fasting glucose and HbA1c comparably to metformin in some studies. Also has antimicrobial effects.
Dose: 500mg, 2-3 times daily, before meals.
Caveats: GI side effects common. Significant drug interactions (CYP3A4, P-gp). Don't combine with metformin without monitoring.