Curcumin downregulates NF-κB, reducing systemic inflammation. Bioavailability is the limiting factor. Pair with piperine (Bioperine) or use a phytosome formulation (Meriva).
Dose: 500-1000mg curcuminoids with piperine, or 250-500mg phytosome form.
Caveats: Thins blood. Pause before surgery. Iron absorption interaction.