Kisspeptin-10 is the 10-amino-acid fragment of the kisspeptin protein — the master regulator of the hypothalamic-pituitary-gonadal axis.
Mechanism — Binds GPR54 in the hypothalamus, triggering GnRH release. GnRH drives LH and FSH from the pituitary, which drive testosterone and estradiol from the gonads. The natural LH surge that triggers ovulation is kisspeptin-mediated.
Use case — Investigational for HPG axis restoration after TRT discontinuation, hypothalamic amenorrhea, and as a diagnostic of axis function. Research dosing varies; typically IV or subcutaneous pulses.
Caveats — Very limited human availability. The upstream nature means it activates the whole axis — not for use when downregulation is desired.