Senolytics are drugs or natural compounds that selectively induce apoptosis in senescent cells while sparing healthy ones.
Mechanism — Target the pathways senescent cells use to resist death (BCL-2 family, PI3K/AKT, FOXO4). Examples: dasatinib + quercetin combo (D+Q), fisetin, FOXO4-DRI peptide, navitoclax.
Use case — Periodic pulse protocols (2-3 days every 4-12 weeks) are the emerging pattern. Fisetin (20 mg/kg) and quercetin (50 mg/kg) are the most accessible natural options.
Caveats — Human data is still building. Don't run senolytic stacks continuously — pulse them. Dasatinib has chemo-drug toxicity at higher doses; don't self-experiment without supervision.